DrugMitochondrial FunctionMitophagyPrimary MechanismMethotrexate (MTX)↓ ATP, ↑ ROS, ↓ mtDNA synthesisPossibly impaired indirectlyFolate cycle inhibitionHydroxychloroquine (HCQ)↑ ROS, mitochondrial dysfunction (via lysosomal pH change)Inhibits lysosomal degradation (blocks...

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